Twentieth Century History of Findlay and Hancock County, Ohio, and Representative Citizens, Part 162

Author: Jacob Anthony Kimmell
Publication date: 1910
Publisher:
Number of Pages: 1189

USA > Ohio > Hancock County > Findlay > Twentieth Century History of Findlay and Hancock County, Ohio, and Representative Citizens > Part 162

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Dionista Daça Chacon: Physician to Charles V, Philip II, Don Carlos and Don Juan of Austria; advocated non-poisonous nature of gunshot wounds.

Francisca Lopez: Physician of Charles V. Extracted Avicenna's Kanon.

Vallesius: Professor at Alcala, published explanations of the aphorisms, later quoted by Boerhaave.

Luis de Lemos: Professor at Salamanca; one of the first to make inquiry into the authenticity of the Hippocratic writings.

Roderigo a Castro: Author of an important treatise on gyne- cology: De universa mulierum medicina opus absolutissi- mum! 1603.

Mercado: Treatises on typhus, gynecology, obstetrics and chil- dren's diseases; famous work on the garrote.

Diaz: Professor at Alcala, known for writings on kidney dis- eases and the relation of vesical calculus to gout.

Boccangelino: One of the best authors of the XVI & the plague.

Francisco Valles: One of the earliest pathological sur who, with Pedro Ximenes, attempted to elucidate . " De locis affectis," by anatomical work.

DESCRIPTION OF PLATES.

FIG. 1 .- " Portrait d'homme dissertant sur une mapy:" Museum at Rouen. , Also known as "Portrait de (ras Colomb " and as "Portrait du Géographe." Attributed ::: and to Carreño. Supposed by Bonnat and Madrazo to retouched by Velasquez many years after it was paiet. Pablillos de Valladolid for a model. "Le mouvement de .: devient tout naturellement un geste de moquerie à la des navigateurs et de ces découvreurs de terres incoer promènent leur curiosité inquiète autour de la mappaz ". le rire épanoui du bouffon se gausse de leurs deer (Louis Gonze: Gazette des Beaux-Arts, 1893.)

FIG. 2 .- Pablillos de Valladolid, sometimes called The Ct- Subject supposed to be the same as that of the Ronen "i- du Geographe."

FIG. 3 .- Portrait of the Bouffon, Pernia. Prado, Mad :: portrait is not regarded as a genuine Velasquez by Ber .:

FIG. 4 .- Don Juan of Austria, Bouffon of Philip IT, to: Madrid. Don Juan of Austria was a natural son of Cta The name was also borne by a bastard son of Philip IT :: actress la Calderona.

FIG. 5 .- El Primo. The Prado, Madrid.

FIG. 6 .- Don Sebastian de Morra. The Prado, Mair .: original was injured by fire and many of its details blir .. FIG. 7 .- Portrait of Antonio d'Ingles. The Prado, Mat"! tonio was the dwarf of Philip IV.

FIG. 8 .- Carlos and his Dwarf. Copley Museum, Bo. FIG. 9 .- El Niño de Vallecas. The Prado, Madrid. FIG. 10 .- El Bobo de Coria. The Prado, Madrid. FIG. 11 .- The Laughing Boy. Called also The Idie! Gallery, Vienna.

FIG. 12 .- Las Meninas. Called by Giordano The Ga Theology of Painting. Las Meninas were girls who ha! assumed the womanly heels: they wore neither mantle: and like the pages in France, served their King and Quee center of the picture stands the Infanta Maria Margar; is receiving a cup of water from the Queen's handmr. Maria Augustina Sarmiento. To her left Doña Isabel de dropping a curtsy. The two dwarfs Maria Barbolo IC and Nicolasico Pertusato (hydrocephalic). A woman guardadamas in mid-background; far back on stalen Queen's aposentador. In the mirror the reflections of : and Queen.

STUDIES IN GLYCOSURIA. I. ETHER GLYCOSURIA.

By JOHN H. KING, M. D., Associate in Pathology, The Johns Hopkins University

and B. S. CHAFFEE, D. B. ANDERSON AND L. H. REDELINGS. (From the Hunterian Laboratory of Experimental Pathology, The Johns Hopkins Medical School.)

The first investigator to call attention to the fact that a reducing body may appear in the urine after etherization was Ruschhaupt (1), who observed glycosuria, in two instances, in rabbits under ether. The presence of reducing materials in the :

logs following ether anaesthesia was independ-

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ently observed by Geis and White and P. B. Hawk. T .. lig (2) undertook a study of the question. In an car he drew attention to several interesting results. T.i. found that ether inhaled for a longer or shorter time : marked glycosuria in healthy dogs. The time of 3 ;.

aft

lit 3 a wi

up in in

de in be

P ir H la

aft

det

hours in another. In general a reducing body will in the urine at the end of one hour if the narcosis is

quantity of reducing body in the urine can, with uresis, amount to 10 per cent, but the average is about per cent. Seelig thought that the glycosuria increased e length of the experiment. The glycosuria lasts only time. It disappears on an average of about 7 hours le discontinuance of the anesthetic, but may last as 16 hours or even 24 hours. The glycosuria depends hyperglycemia, as the sugar in the blood was found :d under the influence of the anesthetic. The increase blood-sugar, however, Seelig points out may not be ·iking.

e glycosuria were dependent upon simple filtration of through the kidney for its occurrence, then the sugar lood should be less after etherization. Such has never und to be the case, in the author's experiments, nor in Seelig thinks that there might be some participation of ney in the process, as he often found albumin in the

· anæsthesia, Seelig states that the glycogen in the less, pointing to this organ as the direct cause of the ycæmia, by increased conversion of glycogen into glu- Ie points out some further interesting results which be found more advantageous to consider later in our Furthermore, in a second paper, Seelig considers the e of diet upon the occurrence of this type of glycosuria. gain it seems preferable to reserve this discussion for nsideration.

: (3) pointed out that during and following ether sia the urine acquired considerable reducing power, but not consider that there occurred a sufficient hyper- a to account for it.

od (4) likewise observed the occurrence of glycosuria her, but also regards its influence on the blood-sugar y slight extent. The cause, he says, is a mystery. He the glycosuria as either due to some permeability of 1 epithelium, or that the anæsthetic may act upon r combination in the blood, increasing the amount of ir, which is then immediately filtered off in the urine. interesting point is raised in this paper as to whether ing property acquired by the urine is due entirely to or in part to some other substance. Upon this point ts may throw some light.

hill (5) states that ether does not cause any notable 1 the sugar content of the blood, when employed in e of slight anesthesia, nor does it induce the passage tcing body into the urine though the anesthesia be. . 3-4 hours.

td seem quite well established that ether, in common ral other drugs, possesses the power of inducing the f sugar into the urine.

muvie minutery the mechanism of ether glycosuria to make a few preliminary experiments to confirm its appearance. Ac- cordingly, several dogs were anæsthetized with the ordinary routine ether for anæsthesia. The anesthesia was deep in every case and the dogs chosen were all healthy active animals. It was found that a very definite reducing property was ac- quired by the urine after ether anaesthesia.

EXPERIMENT No. 1 .- Dog, No. 80. Female. Diet: Meat and bread. Gave 300 cc. of water by stomach tube, 45 minutes before beginning of anesthesia. Anesthesia, 10 a. m. to 12 m. Amount of ether given, 150 cc. The urine drawn just prior to beginning of anesthesia was negative to Fehling's test. At the end of 1 hour, animal was catheterized and 5 cc. of urine obtained. This com- pletely reduced Fehling's solution in a test tube. No. albumin. Catheterized at 3.30 p. m. Urine, 38 cc. Fehling's +. Cathe- terized at 4.45 p. m. Urine, 35 cc. Fehling's +. June 28, 1910, catheterized at 9 a. m. Urine, 120 cc. Fehling's +.

Remarks .- Ether caused the appearance in the urine of a reduc- ing substance at the end of 1 hour, which persisted for 24 hours.

EXPERIMENT No. 2 .- Dog, No. 112. Diet: Meat and bread. Animal was anæsthetized for 5 hours. Urine drawn at end of 20 minutes, after beginning of anæsthesia, reduced Fehling's solution very strongly. Urine drawn by catheter, 36 hours after end of anesthesia, did not reduce Fehling's solution.

EXPERIMENT No. 3 .- Dog, No. 80. Female. Diet: Meat and bread. Gave dog ether from 10 a. m. to 11.30 a. m. Amount, 150 cc. Urine drawn before beginning of anæsthesia was negative to Fehling's, and the polariscope. Urine drawn at the end of anæthe- sia turned the plane of polarized light 1º to right. A specimen of this urine greatly reduced Fehling's solution.

Some yeast was added to a specimen of this urine and allowed to ferment for 22 hours. At the end of this time, the urine was filtered and examined by the polariscope. The plane of polarized light was not turned at all. The urine was also negative for Fehling's. This demonstrates clearly that the reducing property acquired by the urine is due to dextrose.

EXPERIMENT. No. 4 .- Dog, No. 80. Female. Diet: Meat and bread. Dog was given ether from 9.05 to 10.05 a. m. Amount, 13.5 cc. Urine drawn before beginning of anæsthesia was negative for Fehling's. Catheterized at 3 p. m. and 105 cc. of urine obtained. Tested quantitatively by Benedict's method, it showed 0.7304 gm. dextrose.

These experiments will suffice to confirm the previous find- ings in the literature that ether causes a definite glycosuria which may make its appearance as early as 20 minutes after beginning the anesthesia, and disappears by the end of 24 hours. The reducing property of the urine is due to dextrose.

To explain the occurrence of ether glycosuria, it is obviously first necessary to know what changes the anasthetic has upon the sugar content of the blood. Previous experiments from the literature indicate that a hyperglycemia precedes (6) and causes the appearance of sugar in the urine. The results are, however, not in great harmony, and an accurate study of the conditions in the blood seemed desirable at this point. Ac- cordingly several experiments were made to ascertain whether a hyperglycemia occurred after ether anæsthesia and how large an increase in sugar in the blood resulted.

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390

JOHNS HOPKINS HOSPITAL BULLETIN.

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Method .- Healthy adult female dogs were chosen for these experiments. They were all fed upon the same diet, namely, 200 gm. of lean meat daily, and as much water as they chose to drink. Each experiment was conducted in the following manner: Under aseptic conditions and local anesthesia 50 cc. of blood was drawn from the jugular vein into a weighed Erlenmeyer flask containing 5 cc. of 1 per cent sodium oxylate. The whole was then weighed and the weight of the blood thus obtained. The animal was then anæsthetized with ether for two hours and at the end 50 cc. more of blood drawn from the same vein under the same procedure. The animal was then placed in a cage and the urine collected for 24 hours in a re- ceptacle containing 5 cc. of toluol. The blood was examined for sugar by the excellent method of Oppler-Bertrand (7), and the urine for sugar by the method of Benedict and the polariscope.

A word must be said here regarding the influence of diet upon the occurrence of ether glycosuria. Seelig (9) reports that if animals are fed for a long time on carbohydrate diet they do not react to ether by showing a glycosuria. The time necessary for such feeding is generally 3-4 weeks for a medium- sized dog. Occasionally the condition can be brought about in 10 days. However, if fed on a meat diet, the animal re- sponds to the administration of ether by a well-marked gly- cosuria. In all of our experiments, with the exception of the preliminary ones, the animals were fed upon the same diet, namely, 200 gm. of lean meat daily.

The results of the experiments are given below.

EXPERIMENT No. 5 .- Female. Dog, No. B 18. Drew blood from right jugular vein before anæsthesia.

gm.

1. Weight of flask + NaOx + blood =112.30600 Weight of flask + NaOx = 54.86300

Weight of blood = 57.44300 Percentage of sugar = 0.059 per cent dextrose.

Etherized dog for 2 hours, using 250 cc. of ether and at end drew off blood as above.

gm.

2. Weight of flask + NaOx + blood = 106.17210 Weight of flask + NaOx = 54.52900

Weight of blood = 51.64310

Percentage of sugar = 0.141 per cent dextrose.

Increase in sugar of blood due to ether anesthesia = 0.082 per cent dextrose.

Remarks .- A marked increase in the percentage of sugar in blood.

EXPERIMENT No. 6 .- Dog, No. B 15. Female. Drew blood from right jugular vein, before beginning anæsthesia.

1. Weight of flask + NaOx + blood =109.09420 gm. 2. Weight of flask + NaOx + blood = 87.29390 = 36.7959) Weight of flask + NaOx Weight of flask + NaOx == 58.21425 = 50.49600

Weight of blood = 50.77995 Percentage of sugar = 0.031 per cent dextrose.

Etherized dog for 2 hours, using 250 cc. of ether and at end drew off blood as above.

gta.

2. Weight of beaker + NaOx + blood =107.611% Weight of beaker + NaOx = 58.29200

Weight of blood = 49.31999

Percentage of sugar = 0.215 per cent dextrose.

Increase in sugar of blood due to anasthetic =0.184 per Urine was drawn by catheter at end of anesthesia and ! obtained. This strongly reduced Fehling's solution

EXPERIMENT No. 7 .- Dog, No. B 15. Female. Blood tate " left jugular vein before beginning anæsthesia.

1. Weight of flask + NaOx + blood =115.22300 Weight of flask + NaOx = 62.4902)

Weight of blood

= 52.73280

Percentage of sugar == 0.058 per cent. Etherized dog for 2 hours, using 250 cc. of ether, and re drew off blood as above.

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2. Weight of flask + NaOx + blood = 110.96920 Weight of flask + NaOx = 58.13490

Weight of blood

= 52.8343)

Percentage of sugar = 0.113 per cent.

Increase in sugar in blood due to anæsthetic = 0.055 per :

EXPERIMENT No. 8 .- Dog, No. B 63. Female. Blood taler : right jugular vein before beginning anæsthesia.

1. Weight of flask + NaOx + blood = 83.47240

Weight of flask + NaOx = 31.34960

Weight of blood = 52.12260

Percentage of sugar = 0.041 per cent dextrose. Etherized dog for 2 hours, using 250 cc. of ether, and the: blood from vein as above.

2. Weight of flask + NaOx + blood = 93.6143) Weight of flask + NaOx = 40.85850

Weight of blood = 52.75580 Percentage of sugar = 0.159 per cent.

Increase in sugar in blood due to anesthetic =0.118 ; The urine was collected for 24 hours. Amount, 230 ct. no albumin. Sugar, 2.5596 gm.

EXPERIMENT No. 9 .- Dog, No. B 65. Female. Blood takes right jugular vein before beginning anesthesia.

1. Weight of flask + NaOx + blood = 87.82200 Weight of flask + NaOx = 35.63600

Weight of blood == 52.18600

Weight of blood

Percentage of sugar == 0.111 per cent dextrose.

Increase in sugar in blood, due to anesthetic = 0.0657. Urine collected for 24 hours. Amount, 480 cc., no :. - Sugar, 1.0745 gm.

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Percentage of sugar = 0.055 per cent dextrose. Etherized dog for 2 hours, using 250 cc. of ether, and the . blood from vein as above. gın.

WYSY NostiILILS Of experiment.

Weight of flask + NaOx + blood = 88.22560 gm. Weight of flask + NaOx == 38.36390

Weight of blood =49.86170

Percentage of sugar in blood = 0.045 per cent dextrose. g etherized for 2 hours, using 250 cc. of ether, and then blood n from vein as above.

gm.

Weight of flask + NaOx + blood = 86.76400 Weight of flask + NaOx == 36.78050

Weight of blood =49.98350

Percentage of sugar in blood =0.094 per cent dextrose.

:rease in sugar in blood due to anæesthetic =0.040 per cent ose. The urine showed a positive reduction to Fehling's

tese experiments demonstrate conclusively that in healthy following the administration of ether to the point of deep thesia there occurs an increase of sugar in the blood, 1 then passes into the urine and causes the appearance of ucing body in that fluid. In no case did sugar appear in trine, unless the percentage of sugar in the blood was normal.

ese results are collected into tabular form for their more interpretation.

TABLE No. 1.

Gender.

Diet.

Anesthesia.

Length of anesthesia.

Percentage of sugar in

blood before anæs-

Percentage of sugar in

blood after anæsthe-

Percentage of increase

in sugar in blood.

Sugar in urine.

Female.

200 gm. of lean meat daily.

Ether (250 cc).

2 hrs.

0.059%

0.141%

0.082%

Female.

200 gm. of lean meat daily.

Ether (250 cc).

2 hrs.

0.031%

0.215%

0.184%

Female.

200 gm. of lean meat daily.

Ether (250 cc).

2 hrs. |

0.058%

0.113%

0.055%

Female. 200 gm. of

lean meat daily.

Ether (250 cc).

2 hrs.

0.041%

0.159%

0.118%

+ 2.560 gm. dex- trose.

Female. 200 gm. of lean meat daily.

Ether (250 cc).

2 hrs.

0.055% | 0.111%

0.056%

+ 1.075 gm. dex- trose.

200 gm. of lean meat daily.

Ether (250 cc).

2 hrs.

0.045%

0.094%

0.049%

g (9) was of the opinion that the extent of the gly- depended upon the amount of the anesthetic used, at the longer the anesthesia was continued the greater the percentage of sugar in the urine.

the results are given below :

EXPERIMENT No. 11 .- Dog, No. B 61. Blood was taken from the right jugular vein before beginning anæsthesia.

1. Weight of flask + NaOx + blood = 87.47120 gm.

Weight of flask + NaOx =36.74400

Weight of blood == 50.72720

Percentage of sugar in blood = 0.034 per cent dextrose. Dog etherized for 30 minutes, using 25 cc. of ether. Animal was just under the influence of the anæsthetic. Blood was taken at end of anesthesia from right jugular vein.

2. Weight of flask + NaOx + blood = 93.215900 gm.

Weight of flask + NaOx == 39.448900

Weight of blood

== 53.767000

Percentage of sugar in blood = 0.087 per cent dextrose.

The increase in sugar in the blood, due to the anesthetic == 0.053 per cent dextrose. Urine, 150 cc. No reducing bodies.

The same experiment was repeated.

EXPERIMENT No. 12 .- Dog, No. B 61. Female. Animal was bled from right jugular vein before beginning of anesthesia.

1. Weight of flask + NaOx + blood =119.27020 gm.

Weight of flask + NaOx = 70.05150

Weight of blood = 49.21870

Percentage of sugar in blood = 0.046 per cent dextrose.

Dog was then etherized for 30 minutes with 25 cc. of ether. At end of anæsthesia, animal was bled from right jugular vein as above.

2. Weight of flask + NaOx + blood == 111.08180 Weight of flask + NaOx = 60.47790

gm.

Weight of blood = 50.60390

Percentage of sugar in blood = 0.076 per cent dextrose.

Increase in sugar in blood, due to anæsthetic = 0.030 per cent. Urine collected for 24 hours. Amount 280 cc. Acid, albumin none, sugar none.

A second experiment was performed on the same dog, using 100 cc. of ether.

EXPERIMENT No. 13 .- Blood taken before anesthesia from right jugular vein.

1. Weight of flask + NaOx + blood = 90.20300 Weight of flask + NaOx == 41.23510

gm.

Weight of blood == 48.96790 Percentage of sugar in blood = 0.043 per cent dextrose.

Dog etherized for 1/2 hour, using 100 cc. of ether. Dog was deeply under. Blood taken at end of anæesthesia from right jugular vein as above.

2. Weight of flask + NaOx + blood =85.19860 Weight of flask + NaOx == 39.77230

Weight of blood == 45.42630 Percentage of sugar in blood = 0.089 per cent.

Increase in sugar of blood, due to anaesthetic = 0.046 per cent dextrose. Urine collected for 24 hours, 610 cc. Albumin, 0; sugar, +. (Trace by Fehling's test.)

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gm.

Female.

thesia.

Bia.

AV Caducou to test this point, and

392

JOHNS HOPKINS HOSPITAL BULLETIN.

The results of all these experiments show that the extent of the hyperglycemia is more or less dependent upon the amount of the anaesthetic used and the length of the anæs- thesia.

TABLE No. 2.

Dog.

Gender.

Diet.

Anesthesia.

Amount of ether used.

Time of anæesthesia.

Increase in sugar in

Sugar in urine.

B 61

Female.

200 gm. of lean meat daily.

Ether.

25 cc.

30 min. 0.053% |Negative.

B 61

Female.

200 gm. of lean meat daily.

Ether.

25 cc.

80 min .: 0.030%

Negative.

B 61

Female.

200 gm. of lean meat daily.

Ether. 100 cc. 30 min.

0.043%

B 15

Female.

200 gm. of lean meat daily.

Ether. 250 cc.

2 hrs.

0.184%

B 63

Female.

200 gm. of lean meat daily.

Ether. 250 cc. 2 hrs.

0.118%

The occurrence of a hyperglycemia naturally suggests that " we turn our attention to the liver as the most probable organ for its source. What effect does ether have upon the glycogen content of this organ? Seelig (10) reports that the percent- age of glycogen in the liver is diminished after etherization. Another method of investigating the question appealed to us : What would be the effect of removal of the liver from the circulation, upon the occurrence of ether glycosuria ? This condition could be brought about by establishing an Eck fis- tula; then, after the animal had recovered from the effects of the operation, the study could be carried out in the same man- ner as outlined in the previous experiment. The results should indicate conclusively to what extent the liver entered into the mechanism of ether glycosuria.

The experiments are given below. All the animals were upon the same diet, namely, 200 gm. of lean meat daily.

EXPERIMENT No. 14 .- Dog, No. B 36. Female. An Eck fistula was made for us by Drs. Bernheim and Stone. The animal made an excellent, immediate recovery and was allowed to re- cuperate for one week. During this period, the dog was given a liberal amount of bones and water with the regulation 200 gm. of meat. Then she was operated upon aseptically and 50 cc. of blood withdrawn from the right jugular vein before beginning of the anæsthesia.

1. Weight of flask + NaOx + blood = 94.24300 gm.

Weight of flask + NaOx == 44.40810

Weight of blood = 49.83490

Percentage of sugar in blood = 0.055 per cent dextrose. Dog was then etherized for 2 hours, using 250 cc. of ether, and then blood was taken from right jugular vein.

2. Weight of flask + NaOx + blood =121.50790 Weight of flask + NaOx

Weight of blood = 54.64950

Percentage of sugar in blood = 0.0779 per cent dextrose.

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Increase in sugar in blood = 0.022 per cent dextrose. c. anæsthetic. No sugar in the urine.

Remarks .- The increase is very much less than when the. is in the circulation.

EXPERIMENT No. 15 .- Same dog was used again after a t- rest. No. B 36. Female. Blood taken from right jugule:" before beginning anæsthesia.

gm.

1. Weight of flask + NaOx + blood =108.91396

Weight of flask + NaOx = 61.19210

Weight of blood = 47.721801

Percentage of sugar in blood = 0.064 per cent dertres- Animal was etherized for 2 hours, using 250 cc. of ett: then bled from right jugular vein.

2. Weight of flask + NaOx + blood = 120.32900

Weight of flask + NaOx = 66.89800

Weight of blood = 53.43100

Percentage of sugar in blood = 0.089 per cent dextrose Increase in sugar in blood due to anæsthetic = 0.03 x dextrose. No sugar in the urine.

Remarks .- Here again the increase in sugar in bloed anæsthesia is strikingly less than when the liver is in the p circulation.

The dog was turned over to Dr. Whipple for further en ments, at the conclusion of which the animal was killed c: splendid Eck fistula was found to have exsited.

A third experiment was conducted to further contro results.

EXPERIMENT No. 17 .- Dog, No. B 48. Female. We ... pounds. An Eck fistula was established upon this anim !: Bernheim and Stone. The animal recovered well, and was t- post-operatively exactly as in the previous experiment. Bio. taken from right jugular vein before beginning of anæsths

1. Weight of flask + NaOx + blood = 89.623(0) Weight of flask + NaOx == 39.43460

= 50.18840

Weight of blood

Percentage of sugar in blood = 0.066 per cent dextres Dog was then etherized for 2 hours, using 250 cc. of ett-1. then bled from the right jugular vein.

2. Weight of flask + NaOx + blood =86.9550) Weight of flask + NaOx = 39.97390 = 46.9818

Weight of blood

Percentage of sugar in blood = 0.093 per cent dextrose Increase in sugar in blood, due to anasthetic =0.02% - dextrose. No sugar in the urine.

A fourth experiment confirmed the preceding ones. EXPERIMENT No. 18 .- Dog, No. B 48. Female. Dog !. left jugular vein, before beginning of anæsthesia.

1. Weight of flask + NaOx + blood =95.681+ = 46.64 !!

Weight of flask + NaOx .

Weight of blood

Percentage of sugar in blood = 0.059 per cent dest Dog given ether for 2 hours, using 250 cc., and then left jugular vein at end of anæesthesia.

= ===

blood.

gm.

= 66.85840

Weight of flask + NaOx

= 39.42550

Weight of blood =32.65280

ercentage of sugar in blood = 0.050 per cent dextrose.

arks .- Here there is no increase in sugar in blood after but a slight decrease i. e. 0.009 per cent dextrose.

se experiments suffice to show what part the liver takes mechanism of ether glycosuria. When the liver is re- from the circulation and consequently from the effect anæsthetic, there occurs practically no change in the tage of sugar in the blood. This, taken in conjunction eelig's findings of a diminished glycogen content of the 'ollowing ether anaesthesia, establishes the liver as the furnishing the increased sugar to the blood. Of course irculation reaches the liver through the hepatic arteries, lis may account for the very slight change in the per- e of the blood-sugar, but other experiments in which patic artery was tied and cut indicate that the influence hepatic artery is very slight.

ible of the results of these experiments is given below.

TABLE No. 3. ECK FISTULA DOGS.

Gender.

Diet.

Anæstbesia.

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Twentieth Century History of Findlay and Hancock County, Ohio, and Representative Citizens, Part 162

Author: Jacob Anthony Kimmell Publication date: 1910 Publisher: Number of Pages: 1189

Author: Jacob Anthony Kimmell
Publication date: 1910
Publisher:
Number of Pages: 1189